|Season 1, Episode 12c|
|Date Aired:||September 7, 2016|
"San Francisco Madness"
After accidentally destroying their trash-made house while she chased Tweety, Penelope is forced to having Spike and Chester as her guests, much to her dismay. So, Hubie and Bertie start to make their time terrible... for Penelope.
- Penelope Pussycat (voiced by Tress MacNeille)
- Hubie and Bertie (voiced by Bob Bergen)
- Spike the Bulldog (voiced by Maurice LaMarche)
- Chester the Terrier (voiced by Frank Welker)
- Tweety (voiced by Jeff Bergman, cameo)
- "Please, I can tell you... (Spike attacks her)" - Penelope Pussycat.
- "(when he forces Penelope, Hubie and Bertie rebuilt the trash house) Come on, you damn trio, WORK IT IN MY HOUSE!" - Spike.
- This is the first appearance of Penelope Pussycat without Pepé Le Pew.
- This is the first time Hubie and Bertie lost against another character (despite Penelope being the co-loser), Spike and Chester are the winners.
- This segment marks the first appearance of Spike and Chester in the show.